Handbook of Targeted Delivery of Imaging Agents

Author: Vladimir P. Torchilin

Publisher: CRC Press

ISBN: 9780849383083

Category: Medical

Page: 762

View: 3471


This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Targeted Killings

Author: Claire Finkelstein,Jens David Ohlin,Andrew Altman

Publisher: OUP Oxford

ISBN: 0191625906

Category: Law

Page: 520

View: 9997


The war on terror is remaking conventional warfare. The protracted battle against a non-state organization, the demise of the confinement of hostilities to an identifiable battlefield, the extensive involvement of civilian combatants, and the development of new and more precise military technologies have all conspired to require a rethinking of the law and morality of war. Just war theory, as traditionally articulated, seems ill-suited to justify many of the practices of the war on terror. The raid against Osama Bin Laden's Pakistani compound was the highest profile example of this strategy, but the issues raised by this technique cast a far broader net: every week the U.S. military and CIA launch remotely piloted drones to track suspected terrorists in hopes of launching a missile strike against them. In addition to the public condemnation that these attacks have generated in some countries, the legal and moral basis for the use of this technique is problematic. Is the U.S. government correct that nations attacked by terrorists have the right to respond in self-defense by targeting specific terrorists for summary killing? Is there a limit to who can legitimately be placed on the list? There is also widespread disagreement about whether suspected terrorists should be considered combatants subject to the risk of lawful killing under the laws of war or civilians protected by international humanitarian law. Complicating the moral and legal calculus is the fact that innocent bystanders are often killed or injured in these attacks. This book addresses these issues. Featuring chapters by an unrivalled set of experts, it discusses all aspects of targeted killing, making it unmissable reading for anyone interested in the implications of this practice.

Targeted Killing

Author: Markus Gunneflo

Publisher: Cambridge University Press

ISBN: 1316552845

Category: Law

Page: N.A

View: 6451


Looking beyond the events of the second intifada and 9/11, this book reveals how targeted killing is intimately embedded in both Israeli and US statecraft, and in the problematic relationship between sovereign authority and lawful violence underpinning the modern state system. It details the legal and political issues raised in targeted killing as it has emerged in practice, including questions of domestic constitutional authority, the use of force in international law, the law of belligerent occupation, the law of targeting and human rights law. The distinctive nature of Israeli and US targeted killing is analysed in terms of the compulsion of legality characteristic of the liberal constitutional state, a compulsion that demands the ability to distinguish between legal 'targeted killing' and extra-legal 'political assassination'. The effect is a highly legalized framework for the extraterritorial killing of designated terrorists that may significantly affect the international law of force.

Targeted Drug Delivery

Author: Yogeshwar Bachhav

Publisher: John Wiley & Sons

ISBN: 3527827870

Category: Science

Page: 468

View: 822


Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting small molecules as well as peptide and macromolecular drugs, from prodrugs to drug conjugates to drug carriers and devices, helping readers to stay up to date on the latest developments in the field. The following key topics are addressed: Antibody conjugates, prodrugs, and suicide gene therapeutics Protac technology for selectively degrading target proteins Delivery of nucleic acid drugs Novel drug carriers, such as liposomes, vesicles, and nanoparticles Unmet medical needs for which there is a large market potential, such as viral infections and cancer For chemists, pharmacologists, and professionals in the wider pharmaceutical industry, Targeted Drug Delivery is a comprehensive guide on how to solve the greatest challenge in treating many diseases: delivering a pharmaceutically active substance to the target tissue in the body.

Israel’s Targeted Killing Policy

Author: Boaz Ganor,Liram Koblentz-Stenzler

Publisher: Springer Nature

ISBN: 3031136748

Category: Political Science

Page: 236

View: 6138


The book explores the main moral, ethical and operational dilemmas of targeted killings from an Israeli perspective. Even though many countries contending with terrorism have adopted this tool (either overtly or covertly) within the arsenal used in implementing their counter-terrorism policies, it seems that Israel, as one of the world's leading practitioner of targeted killing in its counter-terrorism effort, constitutes the most appropriate case study for reviewing implications and dilemmas associated with this practice. Each chapter will present a different ethical–moral–operational dilemma emanating from a deployment of a targeted killing. The analysis of Israeli considerations and solutions to these dilemmas is built around interviews with Israeli decision-makers, former senior security officials and other experts. The chapters also cover public opinion polls in order to highlight the views of the Israeli public vis-a-vis each dilemma. Finally, chapters will conclude with lessons learned and offer recommendations for a practical and moral solution. The final chapter then draws together universal conclusions and recommendations for the use of targeted killings.

Targeted Jobs Tax Credit

Author: United States. General Accounting Office

Publisher: N.A

ISBN: N.A

Category: Employees

Page: 34

View: 1872


Targeted (Mills & Boon Intrigue) (The Blade Brothers of Cougar County, Book 1)

Author: Lori L. Harris

Publisher: HarperCollins UK

ISBN: 1472034724

Category: Fiction

Page: 224

View: 6876


ZEROING IN Months after his wife had been brutally murdered, FBI profiler Alec Blade was on the desperate hunt to bring her murderer to justice. But after setting up residence in a sleepy Florida town, Alec made a startling discovery: The killer had a new target.

Drones and the Ethics of Targeted Killing

Author: Kenneth R. Himes

Publisher: Rowman & Littlefield

ISBN: 1442231572

Category: Religion

Page: 214

View: 8285


Drones have become an essential part of U.S. national security strategy, but most Americans know little about how they are used, and we receive conflicting reports about their outcomes. In Drones and the Ethics of Targeted Killing, ethicist Kenneth R. Himes provides not only an overview of the role of drones in national security but also an important exploration of the ethical implications of drone warfare—from the impact on terrorist organizations and civilians to how piloting drones shapes soldiers. Targeted killings have played a role in politics from ancient times through today, so the ethical challenges around how to protect against threats are not new. Himes leads readers through the ethics of targeted killings in history from ancient times to the contemporary Israeli-Palestinian conflict, then looks specifically at the new issues raised through the use of drones. This book is a powerful look at a pressing topic today.

Targeted Drug Strategies for Cancer and Inflammation

Author: Ann L. Jackman,Christopher P. Leamon

Publisher: Springer Science & Business Media

ISBN: 1441984178

Category: Medical

Page: 254

View: 8727


Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Targeted Muscle Reinnervation

Author: Todd A. Kuiken,Aimee E. Schultz Feuser,Ann K. Barlow

Publisher: Taylor & Francis

ISBN: 1439860815

Category: Medical

Page: 225

View: 4648


Implement TMR with Your Patients and Improve Their Quality of Life Developed by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantages over other neural-machine interfaces for the improved control of artificial limbs. Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs provides a template for the clinical implementation of TMR and a resource for further research in this new area of science. After describing the basic scientific concepts and key principles underlying TMR, the book presents surgical approaches to transhumeral and shoulder disarticulation amputations. It explores the possible role of TMR in the prevention and treatment of end-neuromas and details the principles of rehabilitation, prosthetic fitting, and occupational therapy for TMR patients. The book also describes transfer sensation and discusses the surgical and functional outcomes of the first several TMR patients. It concludes with emerging research on using TMR to further improve the function and quality of life for people with limb loss. With contributions from renowned leaders in the field, including Drs. Kuiken and Dumanian, this book is a useful guide to implementing TMR in patients with high-level upper limb amputations. It also supplies the foundation to enable improvements in TMR techniques and advances in prosthetic technology.