Author: Nic Sheff

Publisher: Simon and Schuster

ISBN: 1471109739

Category: Biography & Autobiography

Page: 368

View: 3931

THE NEW YORK TIMES BESTSELLER NOW A MAJOR FILM, STARRING STEVE CARELL AND BAFTA AND GOLDEN GLOBE NOMINATED TIMOTHEE CHALAMET ‘It was like being in a car with the gas pedal slammed down to the floor and nothing to do but hold on and pretend to have some semblance of control. But control was something I'd lost a long time ago.’ Nic Sheff was drunk for the first time at age 11. In the years that followed, he would regularly smoke pot, do cocaine and ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling true story of his relapse and the road to recovery. He paints an extraordinary picture for us of a person at odds with his past, with his family, with his substances, and with himself. Tweak is a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery and complements his father’s parallel memoir, Beautiful Boy. Praise for Nic Sheff:- ‘Difficult to read and impossible to put down.’Chicago Tribune 'Nic Sheff's wrenching tale is told with electrifying honesty and insight.' Armistead Maupin

Tweak to Transform

Author: Mike Hughes

Publisher: A&C Black

ISBN: 1855391406

Category: Education

Page: 264

View: 7957

Improving teaching is the key to genuine and sustainable school improvement. Improvement involves persuading teachers to change and develop their practice but, as anyone who has ever tried will testify, this is far from easy. The focus of Tweak to Transform is what head teachers and school leaders can do to manage the change process and improve the quality of teaching in a school. Essentially, Tweak to Transform is a practical handbook that seeks to address three questions. What do we know about change? What do we know about learning? What do we know about leading and managing the improvement process? While there is no single successful recipe for improving teaching in a school, this book attempts to establish some key principles. The result is a collection of thoughts, activities strategies and models that have been developed and successfully implemented in a wide range of schools. >

Tweak It

Author: Cali Williams Yost

Publisher: Hachette UK

ISBN: 1455517860

Category: Business & Economics

Page: 272

View: 6180

As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In TWEAK IT, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes--tweaks--that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.

Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling

Author: Linda C. Burkly,Timothy S. Zheng,John Silke

Publisher: Frontiers Media SA

ISBN: 288919700X


Page: N.A

View: 2998

The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signaling pathways downstream of TWEAK/Fn14, particular attention has been placed on the noncanonical NF?B pathway given that given that TWEAK induces acute activation of canonical NF?B but prolonged activation of noncanonical pathway. Thus dovetailing of the TWEAK/Fn14 axis with noncanonical NF?B pathway activation may be a key mechanism underlying tissue responses. Also of great interest is a deeper understanding of where, when and how tissue responses are regulated by other TNF/ TNFR superfamily members that can signal through noncanonical NF?B. This Research Topic issue will cover: 1. TWEAK/Fn14 pathway biology, role in tissue responses, injury, and disease pathogenesis 2. Role of noncanonical NFkB signaling cascade in tissue responses 3. Translational studies of relevance of TWEAK/Fn14 and noncanonical NFkB in human disease 4. Other TNF superfamily members’ signaling through noncanonical NFkB in the regulation of tissue responses 5. Reviews and Perspectives on the above


Author: James Bryron Love

Publisher: Spangaloo


Category: Fiction

Page: 35

View: 4692

In the multi-verse there exists those that would tamper with the realities of your world. They have the technology to change everything and anything. They even get to decide if you were ever born. They are a nasty sort with out a speck of compassion. There are others bent on balance with the same technology so who is really running the universe?

Tweak Tweak

Author: Eve Bunting

Publisher: Houghton Mifflin Harcourt

ISBN: 0618998519

Category: Juvenile Fiction

Page: 40

View: 4455

While out for a walk, Mama Elephant answers her child's questions about a monkey, a frog, a songbird, a butterfly, and a crocodile, all the while teaching about Little Elephant too.

Tweak it! Second Ed.

Author: Edward Caplan


ISBN: 1300685700


Page: N.A

View: 3095

Restored Power

Author: Jonathan Graf

Publisher: Prayershop

ISBN: 9781935012665

Category: Religion

Page: 128

View: 8072

Restored Power shows in very practical ways how to develop prayer in a church, one step or tweak at a time. It does not offer ideas that are overwhelming to initiate, but rather it provides very easy, practical encouragement.

Space Tweak

Author: Turk Allcott


ISBN: 1300130334


Page: N.A

View: 5023